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Granisetron
It causes antiemetic effect by blocking 5HT3, receptors in brain and peripherally. It can effectively control vomiting due to cytotoxic radio therapy, chemotherapy.
INDICATIONS: Management of nausea and vomiting induced by cytotoxic chemotherapy and radio therapy.
CONTRAINDICATIONS : Hypersensitivity, children below 2 years.
SAFETY PROFILE : Hepatic impairment, liver disease. The drug is to be administered only on the days of chemotherapy.
ADVERSE EFFECTS: Headache, asthenia, somnolence, dizziness insomnia, anxiety, fever, elevation of liver enzymes. AST & ALT.
DRUG INTERACTIONS : Inducer or inhibitors of hepatic cytochrome P450 drug metabolising enzymes: Granisetron does not induce or inhibit the cytochrome P450 drug metabolising enzyme system.
DOSAGE : Adults Injectable 10mcg/Kg IV within 30 minutes before initiation of chemotherapy. Children : Above to 4 years 4-16 years) 10mcg/kg. Adults (Oral) - 2mg once daily (upto 1 hour before chemotherapy) or 1 mg twice daily.