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ESOMEPRAZOLE

It works by decreasing the amount of acid produced by the stomach. Esomeprazole is one of the two stereo-enantiomers in omeprazole. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+ /K+-AT Pase in the gastric parietal cell.

INDICATIONS: Gastroesophagel reflux disease, Healing and maintenance of healed erosive oesophagitis, Eradication of Helicobacter pylori in combination with appropriate antibacterial regimens.

CONTRAINDICATIONS: Hypersensitivity.

SPECIAL PRECAUTIONS: Nursing mothers, pediatric patients, for patients with sever liver impairment, a dose of 20mg of esomeprazole should not be exceeded. Pregnancy.

SIDE-EFFECTS: Headache, diarrhea, abdominal pain, nausea, flatulence, dry mouth constipation, increased creatinine, uric acid, increased or decreased hemoglobin, white blood cell count, platelets, increased bilirubin, alkaline phosphatase, ALT, AST, hypokalemia, hyponatremia, hyperkalemia, hypernatremia, altered thyroid function tests.

DRUG INTERACITONS: Esomeprazole may interfere with the absorption of drugs where gastric ph is an important determinant of bioavailability e.g., keotconazole, iron salts and digoxin.