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ROXATIDINE ACETATE HYDROCHLORIDE

It is a potent and selective H2 receptor antagonist useful in treatment if acid peptic disorders. It markedly inhibits basal, as well as stimulated gastric acid secretion in a dose dependent fashion. Roxatidine has no antiandrogenic activity: no significant effect on hypothalamic-pituitary-gonadal or adrenal axis. Intake of food or antacids has no effect on the absorption of roxatidine and has no adverse drug interacting with benzodiazpines antihypertensives.

INDICATIONS: Duodenal and benign gastric ulcers and reflux oesophagitis. Prohylaxis or recurrent gastric/duodenal ulcers and as maintenance therapy.

DOSAGE: 150mg once daily in the evenin or 75mg twice daily for 4-6 wks. Maintenance therapy; 75mg daily in the evening.

SIDE-EFFECTS: Occasional headache, gastro-intestinal disturbances, rarely dizziness, seep disturbances, restlessness and drowsiness, visual disturbances pain in muscles and joints, hypersensitivity reactions. Transient impairment of sexual drive.