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DIDANOSINE : It is a synthetic purine nucleoside analogue of the naturally occurring nucleoside dexoyadenosine.
Indications: Treatment of HIV infections when antiretroviral therapy is needed.
Dosage: Adults : Dosing interval should be 12 hours. Didanosine should be given 30 min. before or 2 hours after food.
Starting dose : wt < 60 kg : 200mg twice a day, wt < 60 kg : 125mg twice a day.
Contraindications : Hypersensitivity to any com¬ponent.
Special Precautions: Patients with hepatic impair¬ment.
Side effects: Pancreatitis (has been fatal in some cases). Lactic acidosis/severe hepatomegaly with steatosis, impaired renal function; retinal and visual changes; hyperuricemia, impaired hepatic function.
Drug Interactions : Coadministration of didanosine with drugs that are known to cause pancreatitis may increase the risk of pancreatitis. Allopurinol : AUC of didanosine increased. Antacids : Coadministration with antacids containing magnesium or aluminium may potentiate adverse events associated with antacids components. Ketoconazole/itraconazole : Should be given at least 2 hours prior to didanosine. Ganoiclovir : May increase steady state AUC of didanosine. Quinolones : Didanosine should be given 2 hrs. after or 6 hrs. before ciprofloxacin.