lamostad
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LUMIVUDINE : Lamivudine is a synthetic nucleloside analogue with activity against the human immu¬nodeficiency virus (HIV). It belongs to the class of scriptase inhibitors. Lamivudine is the (-) enantiomer of a dideoxy analogue of cytidine.
Indications: Treatment of HIV infection in combination with Zidovudine.
Dosage: Adults: 150 mg twice daily in combination with Zidovudine. For adults with low body weight (less than 50 Kg or 110 Ib): recommended oral dose is 2 mg/Kg twice daily. recommended oral dose is 2mg/kg twice daily.
Paediatric Patients (3 months to 12 years) : 4mg/kg twice daily in combination with zidovudine.
Contraindications: Hypersensitivity, Patients with impaired renal function.
Special precautions: Pregnancy: Use only, if the potential benefits outweigh the potential risk.
Lactation : Not recommended.
Side-effects: Headache, malaise, fatigue, nausea, anorexia, abdominal cramps, neuropathy, insomnia, sleep related disorders, dizziness, depressive disorders nasal sign and symptoms, cough and skin rashes.
Drug Interactions : Trimethoprim 160mg and sulfamethoxazole 800 mg once daily has been shown to increase lamivudine exposure.