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AMANTADINE: It is chemically unique (a tricycline amine) and unrelated to any nucleic acid precursor. It inhibits replication of influenza virus (a myxovirus) at an early stage of the process (prob­ably uncoating of viral nucleic acid).

Indications: Prophylaxis and treatment of influ­enza A. Parkinsonism.

Dosage: Adults: 100 mg 12 hrly for 5-7 days. Children: 5 mg/kg body wt daily.

Contra-Indications: Epilepsy and other C.N.S dis­ease, gastric ulcer.

Special Precautions: Earlier the drug is started, the better.

Side-effects: Insomnia, dizziness, lack of mental concentration, hallucinations, postural hypotension, ankle edema due to local vasoconstriction.

Drug Interactions: Enhances the adverse effects of antimuscarinic agents and levodopa. Thioridazine increases the tremors in Parkinsonium. Enhance effects of benzhexol, orphenedrine. Triamterene and hydrochlorothiazide increases the plasma aman-tadine levels.

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