nevimune
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NEVIRAPINE : It is a non-nucleoside reverse transcriptase inhibitor with activity against HIV-1. It binds directly to reverse transcriptase and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The HIV-2 reverse transcriptase and human DNA polymerases (such as DNA polymerases a, p, y or 8 ) are not inhibited by nevirapine.
Indications: In combination with other antiretroviral agents for the treatment of HIV-1 infection.
Dosage: 200 mg. tablet daily for the first 14 days (this lead in period should be used because it has been found to lessen the frequency of rash), followed by one 200mg tablet twice daily, in combination with antiretroviral agents.
Contraindications:- Hypersensitivity.
Special precautions:- Severe, life-threatening skin reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity. Severe or life-threatenting hepatotoxicity, impaired renal and hepatic function, pregnancy, Lactation.
Side effects:- Rash and increases in liver function tests, hypersensitivity, mild to moderate, maculopapular erythematous cutaneous eruptions.
Drug Interactions: Rifampin/Rifabutin, Ketoconazole, Oral contraceptives, Methadone.