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Recommanded drugs
STAVUDINE : It is a synthetic thymidine nucleoside analogue that possesses virustatic activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2).
Indications: Treatment of HIV-infected patients who have received prolonged prior Zidovudine
Dosage: Adults: 40mg twice daily for patients > 60 kg. 30mg twice daily for patients < 60 kg.
Paediatrics : Starting dose for paediatric patients weighing less than 30 kg is 1mg/kg/dose, given every 12 hours.
Patients should be monitored for the development of peripheral neuropathy.
Contraindications:- Hypersensitivity.
Special precautions:- Lactic acidosis/severe hepatomegaly with steatosis, Peripheral neuropathy, Pregnancy, Nursing mothers, Renal Insufficiency.
Side effects:- Peripheral neuropathy, elevation of hepatic transaminases, headache, chills/fever, diarrhoea, rash, nausea and vomiting, abdominal pain, pancreatitis, myalgia and insomnia.