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GEMCITABINE:It is a nucleoside anaiogue that exhibits anti-tumor activity.
Indication: Aden carcinoma of the pancreas non resctable stage II stage III and stage IV: Indicated in patients treated previously with 5- fluorouracil.
Dosage:Adults: Administered i.v at at dose of 100mg/m2 over 30 minutes, once seekly for up to 7weeks pr of toxicity calls for reducing or holding a dose; followed by a week of rest form treatment subsequent cycles consist of infusions once weekly.
Contraindications: Hypersensitivity. Use in children has not been studied.
Special Precautions: Prolongation of fusion time beyond 60 minutes, more than weekly dosing has been shown to increase toxicity patients should be monitored with complete blood count and platelet count before each dose. Renal and hepatic functions should be evaluated before initiation of therapy and periodically thereafter.
Side effects : Myelo-suppression (Leuckipenia,anaemia, thrombocytopenia), parenthesis, nausea, anorexia, headache, fever, rash renal/hepatic impair net, vomiting, disposal, peripheral , oedema, full like syndrome, asthenia, cough, chills.