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NORADRENALINE BITRATRATE:

Indications: Restoration of blood pressure in certain hypotensive states (e.g. sympathectomy, spinal anaesthesia, MI, septicaemia blood transfusion drug reactions). As an adjunct in the treatment of cadiac arrest and profound hypotension.

Dosage: I.V, infusion : Acid 4ml of the solution to 100ml of 5% dextrose soolution (4mcg base/ml ovserve response to an intial dose of 2-3ml/min adjust rate to maintain a low normal blood pressur (80-100mm Hg systoric). Average maintenace dose 0.5-ml (2-4mcg of base) per minute

Cardiac arrest : Rapid I.V. or intracardiac injecftion 0.5-0.75ml of a solution containing base 100mcg/ml Dose for resucscitation of neonates intants and children: Titrated infusion 1mg/500ml in infants and 2mg/500ml in children

Contra indications: Hypertension.

Special Precautions: Avoid hypertension not a substitute for replacement of blood plasma and fluids. Infusion into a large vein Extravasations may cause necrosis of overlying skin.

Side effects: Bradycardia, peripheral ischaemia hypertension, headache, arrhymias.

Drug Interactions: Bretylium quanethidine halogenated hydrocarbon aneasthetic oxytocic drugs