PRODUCT TYPE:-   VINCRISTINE SULPHATE

BRAND NAME

STRENGTH

PACKING

PRICE

ALCRIST(ALKEM) 1MG 1 VIAL $4.50

CYTOCRISTIN(CIPLA) VINCRISTINE SULPH 1MG + MANNITOL 100MG + METHYL PARABEN 0.13% + PROPYL PARABEN 0.02% 1 INJ. 1ML $1.50

ONCOCRISTIN-AQ(SUN) 1MG/ML 1 INJ. 1ML $1.50

VINCRISTINE: It is mitotic inhibitor, binds to microlubular protein tubulin and cause disruption of mitotic spindle. The chromosomes fail to move apart during mitosis: metaphase arrest occurs. They are cell cycle specific and act in the mitotic phase. It is rapidly acting drug but not good for maintenance therapy.

Indications: inducing remission in childhood acute leukemia, lymphosarcoma. Hodgkin's disease, Wilm's tumour. Ewing's salcoma and carcinoma lung.

Dosage: Children : 2mg/sq.m. body surface.

Adults: 1 4 mg/sq.m. body surface.

Contra-indications: Pregnancy.

Special precautions: Acute uric acid neuropathy may occur. Reduce bone marrow reserve, impaired

Pediatrics: Adjust dose according to body weight.

Pregnancy: Should not be used.

Lactation: Use with caution. Bone marrow depression.

Drug Interaction: Potentiation of other myelosuppressive drugs. Acute bronchospasm with mitomycin C. May decrease digoxin serum levels Synergislic with methotrex.