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Alkeran ( Melphalan)
US Brand: Alkeran Manufacturer: Other
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MELPHALAN: It is very effective in multiple myeloma, bone marrow epression is its most indications: Multiple myeloma, Breast carcinoma. Advanced ovarian carcinoma, and other malignant
Dosage: 10 mg daily for 7 days or 6 mg/day for 2-3 wks- 4 wks gap -2-4 mg daily maintenance orally.
Contraindications: Hypersensitivity, pregnancy,
Special Precautions: Haernatological monitoring is required during therapy.
Pediatrics: Contraindicated in infants.
Pregnancy: Should not be used.
Lactation: Should not be used.
Elderly: Use with caution.
Side-effects: Menstrual irregularities pulmonary fibrosis, alopecia, bone marrow depression, haemolytic anaemia.
Drug Interactions: Potentates risk to renal dam-pretreatment with cyclophosphamide, antineoplastjc action potentiated by rednisone