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PRODUCT TYPE:- ALLOPURINOL
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ALLOPURINOL: Its major metaolite alloxanthine is long acting and non competitive inhibitor primarily responsible for uric acid synthesis inhibition. Drug allopurinol administration, plasma concetration of uric acid reduced and that of hypoxanthine and xanthine is increased
Indications: Chronic gout, Secondary hyperrricaemia, due to cancer chemothrapy radiation & thiazies or drugs. prevention of uric acid nephropathy. Calcuim renal lithiasis.
Dosage: Initially 10000mg daily maint: 200-600mg daily.
Contra Indications: Children, Acute gout.
Special Precautions Both allopurinol and uricosurics should not be started during acute attack of gout. Iron therapy not advised with allopurinol. Renal or hepatic impairment Maintain adequate fluid intake.
Pediatrics: Reduced dose necessary.
Pregnancy: Should not be used
Lactation: Use with caution
Elderly: Reduced dose may be necessary pain, gastric irritation, headache, nesa, liver damage.
Drug Interaction: Dose of Azothioprine and mercaptopurine should be reduced when adminisurinary excretion of allopurinol. Enhance activity of oral hypoglycaemic agents and anticoagulants.