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Atorvastatin with Ezetimibe
Ezetimibe with atorvastatin improves LDL-C, HDL triglycerides, cholesterol (HDL-C), total cholesterol:HDL-C, and high-sensitivity C-reactive protein (hs-CRP) This combination provides a significant additional 12% LDL-C reduction, 8% triglyceride reduction, 3% HDL-C increase, and 10% hs-CRP reduction versus atorvastatin alone. Atorvastatin With Ezetimibe reduces low-density lipoprotein (LDL) cholesterol more than either alone. Combined with atorvastatin (low dose), ezetimibe achieves reductions similar to those seen with atorvastatin alone in LDL cholesterol.
There is no proven fact that atorvastatin reduces mortality or cardiovascular morbidit. Combining ezetimibe with atorvastatin can be a good alternative for patients already on high-dose atorvastatin. Ezetimibe is a newer drug. It prevents intestinal absorption of cholesterol..
Technical detail
ATORVASTATIN WITH EZETIMIBE : Atorvastatin and Ezetimibe are hypolipidamic agents both have a different mode of action which isoften necessary ot achieve a desired satifactory reduction in lipid levels
Indications: Primary hypercholesterolemia, homozygous familial hyperchloemia homozy hous sitosterolemia heterozygous familial hypercholesterolemia combined hyperlipidaemia hyperlipoporteinaemia, hypertriglyceridaemia hyperlipidemia associated with hypertension and type II diabetes.
Dosage: Atorvastatin 10mg and Ezetimibe 10mg orally once daily.
Side effects: Anoredia, nausea, vomiting abdominal pain headache insormina erversible myositis chest pain alopecia impotence altered LFTs hyperglycaemia hypoglycaemia.
Contra Indications: Hypersensitivity active liver disease, pregnancy lactation paediatrics
Special Precautions: Hepatic insufficiency high alcohol intake unexplained muscular pain tenderness or weakness mutagenesis carcinogenesis impairment of infertility
Drug Interactions: Antacids, colestripol digoxin erythromycin.