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ANASTROZOLE:Anastrozole is a new generation no steroidal aromatizes inhibitor, which selectively and potently blocks the enzymatic synthesis of estrogen form androgen.
Indications:Advanced breast cancer in postmenopausal women.
Dosage:1mg daily.
Contra-indications: Pregnancy and lactating; moderate or severe hepatic disease/renal impairment. Premenopausal women.
Special Precautions:Estrogen containing therapies should not be used with anastrozole as they may diminish its pharmacological action. Taxoifen should not be co-administered with anastrozole.
Side effects: Hot flushes, caginal dryness, vaginal bleeding, hair thinning, anorexia, nausea, vomiting diarrhea, headache, arthralgia bone fractures, rash (including Stevens-Johnson syndrome). Asthenia and drowsiness Amy initially affect ability to drive or operate machinery.