aredia
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Aredia (other)
US Brand: Aredia
Manufacturer: Other
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Indications: Hypercalemia of malignancy, Paget's disease, Osteolytic bone metastases of breast
Dosage: Hypercalemia of malignancy: Treatment would depend on the severity as well as symptoms of hypercalcemia. In mild hypercalcemia, vigorous saline hydration alone may be sufficient. The recommended dose of pamidronate in moderate hypercalcemia (corrected serum calcium of approx. 12 to as an initial, single dose intravenous infusion over 24 calcium of approx, > 13.5mg/dl) is 90 mg. The 90mg nous infusion over 24 hrs. Paget's disease : The recommended dose of pamidronate in patients with moderate to severe Paget's disease of bone is 30mg secutive days for a total dose of 90mg. Osteolytic bone of multiple myeloma : The recommended dose lesions of multiple myeloma is 90mg, administered as a 4-hour infusion given on a monthly basis. Osteolytic bone metastases of breast cancer ; The recommended dose of pamidronate in patients with osteolytic bone metastases is 90mg, administered over a 2-hour infusion given every 3-4 weeks.
Contraindications: Patients with clinically significant hypersensitivity to pamidronate or other biphosphonates.
Side effects: Fluid overload, generalized pain. Hypertension. Abdominal pain, anorexia, constipation, nausea, vomiting. Urinary tract infection. Bone pain. Anaemia, hypokalemia, hypomagnesemia, hypo-phosphatemia.
Special Precautions: Hepatic impairment Paediatrics: indicators in certain Standard hypercalcemia related metabolic parameters such as serum levels of
should be carefully monitored.