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LOVASTATIN : It is absorbed form GIT. It under goes extensive first pass metabolism in liver which is the primary site of action it is highly bound to plasma protein. Absorption is reduced by approximately 30% when administered on an empty stomach their than with food Lavastatin is eliminted primarily through fecal route which is the 83$ of orally administered dose 10% of drug is eliminated by renal route.

Indication: an adjunct to diet for the reduction primary hypercholesterolemia for reduction of elevated LDL cholesterol levels in patients with combined Hypercholesterolemia and hypertriglycerdemia.

Dosage: 10-80 mg/day in single or divided doses.

Contra Indications: Hypersensitivity active liver disease or unexplained persistent elevations of serum tranaminases, pregnancy & nursing.

Special Precaution: Pregnancy & Lactation.

Side effects: Flatulence, diarrhea, constipation nausea, and abdominal pain cramps myopathy myalgia rhabdomyolsis, blurred vision headache, dizziness rashes, imptoene imsomnia.

Drug Interaction: Anticoagulants comarin-or indandione derivative GMG-COA reducatase inhibitors cyclosprine erythormiyin Gemfibrozil immunosuppesants or niacin.