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PROBENECID: Uric acid is largely reabsorbed by active transport, while less of it is secreted. Probenecid therefore promotes its excretin and reduces its blood level. It is neither analgesic nor anti-inflammatory.

Indications: Chronic gout. Secondary hyper uricaemia due to drugs or disease.

Dosage: Initially 0.25 g twice daily gradually increased to max 1mg twice daily. Not recommended for children

Contra Indications: Blood dyscrasias. Renal uric acid stones. Therapy initiation during acute attack.

Special Precautions: Peptic ulcer. Pregnancy renal impairment. Maintain adequate fluid intake.

Pediatrics: Not recommended for children under 2years
Pregnancy: use with caution.
Lactation: Use with caution
Elderly: Reduced dose may be necessary

Side effects : DIpepsia rashes, convulsions Toxic dose may causerespiratory failure

Drug Interactions: Thiazides, aspirin alcohol reduce its efficacy. Enhances effects of oralantidiabetics, indomethancin, sulfonamides, acyclovir , methotrexate.