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CISPALTIN/CARBOPLATIN:It is a platinum coordination complex. It causes cross linking of DNA; favored site being N7 of guanine residue. It can also react with-SH groups in proteins and has radiomimetic property. It bound to plasma proteins, enter, tissues & is slowly excreted unchanged in urine/ Cisplatin is very effective in metastasis testicular & ovarian carcinoma. It has found use in some other solid tumors as well.
Indications:Metastasis testicular and ovarian carcinoma, advanced bladder, head & neck cancer.
Dosage:Admin: Pregnancy, lactation, hypersensitivity, renal impairment.
Special Precautions:Maintain good hydration shock like state sometimes occurs during i.v infusion. Monitor hematological, neurogical status & renal functions. Hypomagnesaemia. Hypocalcaemia. Hyperuricaemia.
Pediatrics: Not usually prescribed. The risk of hearing loops is increased
Pregnancy: Not usually prescribed.
Lactation: Not advised.
Elderly: Reduced dose may be necessary.
Side effects:Nausea, vomiting, Tinnitus, deafness, nauropathy, nephrotoxicity, electrolyte imbalance.
Drug Interaction: Potentates neurotoxicity with aminoglycosides.