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CABERGOLINE: It is a long acting dopamine receptors, but having low affinity for dopamine D1 a1 a2 adrenergic and 5-HT1 and 5-HT2 serotonin receptors. It directly inhibits prolactin levels.

Indications: Hyperprolactinemic disorders either an idiopathic or due to pituitary adenomas.

Dosage: Administered orally. No interference by concomitant food intake. Starting initial dose is 0.25 twice weekly. Dose may be increased in increment of 0.25mg every four weeks as needed according to body prolactin levels, up to 1mg twice a week. Discontinue the drug only when a normal serum prolactin level has been maintained for 6 months.

Contra Indications: Hypersensitivity to cabergolin or other ergot alkaoid. Uncontrolled hypertension.

Special Precautions: Untreated hypertension or pregnancy induced hypertension (preeclampsia and eclampsia). monitor LFTs.

Pediatric: Safety and effectiveness not established.
Pregnancy and Lactation: Use with caution if clearly indicated.
Elderly: Use with caution if clearly indicated.

Side effects: Allergy, gastrointestinal intolerence, asthenia, fatigue, ful-like syndorme, malaise, hot flushes, edema, weight changes, somnolence. depression, nervousness, anxiety impaired concentrating, very rarely cardiac failure and cnstructive perivarditis, musculoskeletal pain, respiratory affection, abnormal vision breast pain, dysmenorrheal, decreased libido overdose may produce nasal congestion, syncope or halucinaltion.

Drug Interaction: D2 antagonists such as phenothiazine butyrophenones, thioxanthenes, metoclopramide, antihypertensives metoclopramide, antihpertensives.