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DOXORUBICIN: Vs a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumors. Doxorubicin is capable of causing breaks in DMA strands and have rnutagenic
exerted at S phase, but toxicity is usually exhibited in G2 phase.
Indications: Malignant lymphoma. gastro-iniesti--«al tract carcinoma. Bronchogenic, bladder, breast
eioblastic leukaemia, soft tissue & bone sarcomas.
Dosage: 1.2-2.4 mg/kg body wt or 60-75 mg/sq
metre of body surface given as a single dose every
3 weeks by slow i.v. Inj.
Contra-indications: Cardiac disease. Hepatic
dysfunction.
Special Precautions: EGG changes, arrhythmias, hypotension, or be delayed congestive heart failure. Pediatrics: Reduced dose .necessary. Pregnancy: Not usually prescribed. Lactation: Not prescribed. Elderly: Reduced dose may be necessary. .
Side-effects: Cardiotoxicity, alopecia, Marrow depression, alopecia, cardiomyopathy, stomatitis, vomiting and local tissue damage.
Drug Interactions: Cyclosporin, cardiotoxic agents potentiates the cardiotoxicity.