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LEUCOVORIN: Folinic acid (Leucovorin) is an active conezyme form and dose not need to be reduced by DHF Rase before it can act. Methotrexate is a DHF Rase inhibitor; its boxicity is not counteraced by folic acid but antagonised by tolinic acid

Indications: Antidote for methotrexate & folic acid antagonisits.

Dosage: Dose equal to antagonist given; to be given within 1 hr. Usally ineffective if given after 3hrs.

Contra Indications: Ernicious anaemia and megaloblastic anaemia secondary to the lack of vit B12.

Special Precautions: Undiagnosed megloblastic anaemia folate dependent tumors.

Pediatrics: Use with caution.
Pregnancy: safety not established
Lactation: Safety not established
Elderly: May cause severe G.I disturbances and other adverse effects.

Side effects: Allergic sensitizaton, nausea, pyrexia, comiting, urticaria, anaphylactic reactions.

Drug Interactions: Enhances cytotoxic effect of fluorouracil. Reduces methotrexate toxicity. Phenobarbitone, phenytoin primideone counteracts the antiepliteptic effects.