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CYTOSINE ARABINOSIDE (Cytarabins): It is phosphorylated in the body to corresponding nucleotide, which inhibits DNA synthesis. It also interferes with DNA repair. Cytorabine is cell cycle specific and acts primarily during S phase. Its main use is to induce remission in acute leukemia.
Indications: Acute leukaemias, lymphosarcomas.
Dosage: 3-6 mg/kg body wt i.v daily in 2 divided doses for 5-10 days.
Special Precautions: Hepatic impairment. Pediatrics: Indicated in certain leukaemia, under strict supervision. Pregnancy: Safety not established Lactation: Safety not established Elderly: Use with caution.
Side-effects: Bone marrow suppression. G.I.T disturbances.
Drug Interaction: Potentates bone marrow depression with radiotherapy and other myelotoxic drugs. Reduces plasma concentratrion of digoxin, antagonises genlamycin. Decreased efficacy of flurocytosine.