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PROPOFOL: It so a surgical anaesthetic having rapid/predictable induction, non accumulation quick/smooth emergence, good tolerance, minimal cardio respiratory adversity on careful administration
Indication: Induction or maintenance of anaesthesia in cardiology, neurology, pediatric surgery. ICU sedation/vomiting intubation pruitus sedation following cardiac surgery. Torticollis cardiovascular. MRI malignant hyperthermia obstetric analgesia.
Dosage: It should be administered intravenously.
General anaesthesia : Induction : Adult: 2-2.5mg/kg.
Elderly: 1-1.5 mg/kg children: 2-5-3.5mg /kg over 20-30 secs, Maintenance: Adult: 6-12mg/kghr, Elderly : 3-6mg/kghr, Primary & Secondary opiodis : 50-100 & 100-150 resp. Neurology:6-12mg/kg/hr. children : 7.5-18mg/kg/hr
Maintenance intermittent : Adults : 20-50mg in crement as requires.
Monitored anaesthesa care : Initiation : 6-9 mg/kg/hr over 3-5 min or 0.5mg/kg over 3-5 min.
Maintenance: Adults: 1.5-4.5 mg/kg/hr others. 80% of the adult
ICU sedation: Initiation: 0.3 mg/kg/hr for 5 min or more folowed by 0.3-0.6 mg/kg/hr increment over 5-10 min. Maintenance: 0.3-3mg/kg/hr
Contra Indications: Hypersensitivity.
Special Precautions: Hypovoleamia, epilepsy dysipidaemia, increased ICP, ECT, concurrent medications.
Pediatrics: General anaesthesia in age below 3 yrs. and MAC all aged not recommended
Pregnancy: Anesthesia: Use only if clearly indicated. Not recommended during delivery time.
Lactation: Not recommended
Elderly: Reduce dose as per body weight
Side effects: Severe pain on injection postoperative nausea/comiting neuromuscular excitation, opthalmplegia, rash anaphylaxi tolerance abuse potential green increased recovery time.
Drug Interactions: Opioids,muscle retaxants/neuromuscular blockers increase anasthesia, respiratory depression (opiods) and decrease the HR (suxa methonium) heart block/asysote Midazolam, thoipentol fentanly, alfentanyl increasese hyposis.