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HYDROXYUREA: Primary site of action is enzyme ribonucleoside diphosphale reduciase. The drug is specific for S phase of the cell cycle and causes cell to arrest at the G,-3 interface. Indications: Chronic myeloid leukaemia. Solid
Dosage: Chronic myeloid leukaemia: 20-30 mg/ kg/day in single doses. Solid tumors: 80 mg/kg as a single dose every 3rd day.
Contraindications: Marked bone marrow 'depression, severe anemia, pregnancy, lactation,
toring, renal & hepatic fumction monitoring; recent dren.
megaloblastic changes. Erythema caused by irradiation may be exacerbated by hydroxyurea. Gastrointestinal disturbances, impairment of renal function, pulmonary oedema, mild dermatological reac-
Drug Interactions: Risk of hematological toxicity increased with concomitant use of cytarabine.result in manifestations of infection in patients on cylotoxic drugs. CNS depressants enhance the drowsiness side effect of hydroxyurea.