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Etoposide
Etoposide phosphate is an inhibitor of the enzyme topoisomerase II. This drug also has the brand names like Etopophos, Eposin, VP-16Vepesid. Etoposide is often given with other medicines. Its chemical make-up is derived from podophyllotoxin, which is a toxin found in the American Mayapple.
It is used as a form of chemotherapy for the disease like lymphoma, Ewing's sarcoma, testicular cancer, lung cancer, glioblastoma multiforme and non-lymphocytic leukemia. While giving this drug, the blood pressure of the patient should be checked often. It is given intravenously or orally in capsule form. It is advised to take the medications as prescribed by a qualified physician.
Technical detail:
ETOPOSIDE: V It is a recently developed-serni-synthetic derivative of podophyllotoxin, a plant glycoside. It is not a rnitotic inhibitor, but arrests cells in the G2 phase. It has been primarily used in testicular tumors, lung cancer. Hodgkin's & other lymphomas.
Indications: Small cell lung cancer, Malignant lymphomas, Acute leukaemias, Testicular tumours.Bladder cancer & trophoblastic diseases.
Dosage: Dose in combination with other chemoth erapeutic agents: 50-100 mg/sqm body surface area/ally on days through 5 to 100 mg/sqm BSA/ daily on days 1, 3, 5. Give a gap of 3-4 wks to recover from toxicity before repeating. Contraindications: Hypersensitivity severe liver dysfunction.
Special precautions: Renal disease, infections, avoids contact with the skin, mucosa and eye. Pediatrics: Safety not established. Pregnancy: Should not be used. Lactation: Should not be used. Rh'^-iv: Safe. Side-effects: Alopecia, G.I.T. disturbances, nautis, myclosuppression.
Drug Interaction: Synergism with other cytotoxic drugs