fludin
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5-FLUOROURACIL: It is pyrimidine analogue and is converted in the body to the corresponding 5 fluoro-2-deoxyuridine monophosphate, which inhibits thymidylate synthetase and blocks the conversion of beoxyuridilic acid to deoxythymidylic acid. Selective failure of DNA synthesis occurs due to non-availability of thymidylate: thymidine can partially reverse its toxicity.
Ion, urinary bladder, liver, pancreas, adjuvant to surgery, radiotherapy & other chemotherapeutic drugs. Topical application in cutaneous basal cell
Dosage: 12 mg/kg body wt once daily for 4 successive days i.v. Max daily dose: 800 mg.
Contra Indications: Pregnancy, Depressed bone marrow function, serious infections, Poor nutritional state.
Special Precautions: Careful care at some Hospital or nursing home must for 1st course of treatment.
Pediatrics: Should not be used.
Pregnancy: Should not be used.
Lactation: Should not be used.
Elderly: May increase the adverse effects.
Side-effects: Toxicity on bone marrow & G.I.T.
Nausea, vomiting, Skin pigmentation.
Drug Interactions: Leucovorin calcium enhances the toxicity of fluorouracil.