imatib
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IMATINIB MESYLATE: It is aprotein-tyrosine kniase inhibitor that inhibits Bcr-Abl tyrosine kinase it is also an inhibitor of the receptor tyrosine kinases for platelet derived growth factor and stem cell factor. C-kit and inhibit their mediated cellular events
Indications: Phliadelphia cohromosome positive chronic myeloid leukemia (CML) Kit (CD117) positive unersevtable and/or metastaic malignant gastroninestinal stromal tumors (GIST).
Dosage: To be administered roally with a meat and a large glass of water. Range of dosage to be adjusted according to therapeutic response and adverse effects.
Chronic Phase CML : 400mg-600mg/day
Accelerated Phase ro blast crisis CML : 600mg-800mg/day (400mg twice daily)
Unresectable and/or metastatic malignant GIST : 400mg-600mg/day
Contra indications: Hypersensitivity
Special Precautions: Dose adjustment/reduction or treatment interruption is recommended it a severe adverse effect develops.
Pediatric: Safety and efficacy have not been established under the age of 18-years of age
Pregnancy: Safety is not established.
Lactation: Safety is not established
Elderly: Safe
Side effects: Nausea, vomiting diarrhoea abdominla pain, rash edema, and muscle carmps. Local or generalised fluid, retention and rapid weight gain Cytopenlas Hepatotoxicity.
Drug Interactions: Ketoconazole, itraconazole erythromycin, and clarithromycin may increase plasma concetration of imatinib, while dexamethasone. Phenytoin carbamazepine rifampicin phenobarbital may decrease the plasma concentration of imatinib it will increase plasma concentration of triazolo-benzodiazepines, dihydrophridine, calcium chnnels blokcers, Certain HMG-GoA reductase inhibitors etc. Warferin.