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L-ASPARAGINASE: Observing the qualitative difference observed between normal cells and those form childhood lymphoblast leukemia-the leukemia cells are deficient in L- asparagines synthetics and depend. The enzyme L-asparagines (from E. chili) degrades Asparagines to Aspartic acid.depriving.leukemic cells of an essential metbolite-may cause cell death.

Indications: Acute leukemia. Malignant lymphoma.

Dosage: 50-200 i.e. body wt. daily or every alternate day by ivy. infusion

Contra-indications: Hypersensitivity.

Special Precautions: Anaphylaxis can occur. allergic reaction (being a foreign protein).

Pediatrics: Safe.
Pregnancy: Should not be used.
Lactation: Should not be used.
Elderly: Use with caution

Side effects: Liver damage, panceratitis & C.N.S symptoms (due to defective protein synthesis).

Drug Interactions: Incrusting and perdnisolone increase the toxicity, diminishes or abolishes the effect of tolerate on malignant cells.

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