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MEDROXYPROGESTEFTONE ACETATE: It is a synthetic steroid active by the oral route derived /from progesterone. prostatic adenoma.

Dosage The dosage can vary from 100 to 1000mg/ day(higher dose can be divided into two-three daily

Contraindications: Thrombophlebitis, thramboembolic disorders, severely impaired liver function, unknown origin, hypersensitivity to the drug.

Special Precautions: Use in pregnancy not recommended because of a possible association between administration of progestins early in preg­nancy and congenital heart defects in the offspring.

Disorders occur In cases of undiagnosed vaginal bleeding, adequate diagnostic measures are indi­cated.

Side Effects: Breast tenderness, galaciorhaea vaginal bleeding, changes in menstrual flow, amenorrhea, edema, change in weight, changes in cervical erosions or cervical secretions, cholestatic jaundice, rash with or without pruritus, psychic

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