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MITOXANTRONE:
Indications:Adult acute non-lymphocyte leukemia, Carcinoma of breast, non-Hodgkin’s lymphoma, chronic myelogenous leukemia.
Dosage: Initially 14 mg/sqm. Body surface area as single i.v dose repeat after 21 day interval.
Contra-indications: Severe myleosupperssion abnormal cardiac function form prior anthracyline exposure.
Special Precautions: History of cardiac disease. Periodic blood count and monitor cardiac Function. Prior radiotherapy. Anthracycline therapy. Concomitant cytotoxic therapy.
Pediatrics: Contradicted.
Pregnancy: Contradicted.
Lactation: Contradicted.
Elderly: Use with caution.
Side effects: Rash, Dysnoea, phlebitis, cardio toxicity