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BUSULPHAN: It is an alkylating agent which is highly specific for myeloid elements; granulocyte precursors being most sensitive, toil owed by those of platelets and R.B.C. It produces little effect on lymphoid tissue and G.l.T. Indications: Myelofibrosis, chronic granulocytic leukaemia, polycythaemia vera, essential
Dosage: 2-6 mg/day (0.06 mg/kg/day) orally.
Contraindications: Bone marrow suppression cronic lymphocytic laukaemia, acuteleukaemia doubtful CML diagnosis CML blast
Special Precaution: Pregnancy, lactation Therapy should be initiated after hospitalization
Side-effects: Hyperuricaemia, pulmonary fibrosis Bone marrow suppression, hyper pigmentation.