2d Ofloxacin Ornidazole
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OFLOXACIN:
Indications: Genito urinay, respiratory, Gastro intestinal, skin & skin soft tissue infections. Peritonitis, Gonorrhoea.
Dosage: Adults: 200-400 mg daily usually for 5-7 days depeding on type and severity of infection doses greater than 400mg should be given in 2 divided dose.
Urinary tract infection : 200-800 mg daily lower respiratory tract infection 400-800 mg daily Gronorrhea, 400 mg as a single dose.
Not recommended for children :
Contra - indications: Hypersensitivity to 4 quinolones. History of epilepsy.
Special Precautions: Exposure to strong us light and ultra violet rays should be avoided. Driving or operating machinery. Renal insufficiency. Psychiatric disorders concomitant use of aluminum and magnesium containing antacids.
Pediatrics: Safety not established in children below 16 years.
Pregnancy: Contraindicated.
Lactation: Contraindicated.
Elderly: Safe.
Side effects: Hypersensitivity reaction skin reaction, CNS disturbances G.I. upset peseudomem branous colitis. Transient increase in liver enzymes.
Drug Interactions: Antacids containing magnesium and aluminium reduce absorption. Sucralfate reduced absorption. Inhibits GABA receptor binding provenecid decreases elimaination.