3a Azithromycin
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AZITHROMYCIN: It is an azalide antibiotic, a subclass of the macrolides. It retains the sublass of the macrolides. It retains the spectrum of activity of erythromycin against. Gram-positive and Gram-negative pathogens and has increased activity against many Garm-negative and atypical micro-organisms. It has greater acid-stability than erythromycin and its gastrointestinal tolerance is better than that of erythromycin. It acts by terfering with microbial protein synthesis by binding to the 50 s ribosomal subunit.
Indications: Upper and lower respiratory tract infections, sking and soft tissues infections. Uprogenital infections.
Dosage : Upper and lower respiratory tract and skin and soft tissue infections : 500mg once daily for 3 days or 500mg once on Day 1 followed by 250 mg once daily for the next 4 days Urogenital infections (Chalamdial) 1g as a single dose Azithromycin should be taken 1 hr before or at least 2 hours after a meal
Contraindications: Hypersensitvity ot azithromycin ro other macrolides.
Special Precautions: Pseudomembranous colitis, impaired liver function, impaired renal function antacids, containing aluminium and magnesium. children.
Pediatrics: Reduced dose necessary. Not recommended in children below the age of 6 months.
Pregnancy: Use with caution
Lactation: Use with caution.
Elderly: No special problem.
Side effects: Nausea, vomiting, abdominal pain diarrhoea, dyspepsia, flatulence, dizzines headache, vertigo.
Drug Interactions: Absorption reduced by food. Antacids reduced rate of absorption. Increases absorption of Digoxin and Cyclosporine