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CIPROFLOXACIN: It is a new fluoroquinolone antimicrobial agent with potent activity against a broas specturm of gram-positive & gram-negative bacdteria including Ps. acruginosa, Enterbacte riaceae and Staph aureus. Ciprofloxacin dose not disturb normal anaerobic intestinal flora and has signficany post-antibiotic effect & thus prevents regrowht of gacteia. Its antibacterial spectrum is wider than of aminoglycosiris, thrid genaration cephalosoprins and other fluoroqulonones.
Indications: Respiratory tract. Urinary E.N.T skin and soft tissce. Gastro intestinal tract intra-abdominal. Gynaecological Bone and joint and severe systemic infections. Gonorrhoea. Cliprofloxacin 400mg/200 ml IV infusion 12 hourly is indicated for systemic infection lower respiratory tract infections . Skin and skin structure infections typhoid fever severe/complicated urinary tract infections, surgical procedure.
Dosage: The dosege of Ciprofloxacin is datermined on the basis of severity of infection type of infection organism and age, weight and renal functions of the patient. The recommended dosage schedule of oral Ciproflxacin is as follows:
- Uncomplicated UTI : 250 mg every 12 hours.
- Prostatitis and complicated UTI in patients with severe underlying structural abnormalites
500mg every 12 hours.
- Lower respiratory tract infections mild-250 mg moderate to severe -500 mg all every 12 hours. Dosage of 750 mg every 12 hours should perferably be used in cases of infections with resistant gram-positive bacteria.
- ENT infections : 500 to 750 mg every 12 hours.
- Bone and joint infections : 500 to 750 mg every 12 hours.
- Gastroentertis. 250mg every 12 hours
- Enteric fever 500mg every 12 hours.
- Gynaecological infections : 500mg every
- Gonorrhoea : 250mg single dose.
- Speticemia, bactermia and intra-abdominal infections : initial IV ciprofloxacin therapy may be followed by oral 500 to 750 mg every 12 hours