Alcefor
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CEFOPERAZONE SODIUM:It is a broad specturm antibiotic, with high clinical efficacy and good toleration profile. Can be administered as monotherapy or combination therapy in infections.
Indications: Respiratory tract infections. U.T.I Peritonist. cholecytitis cholangitis and other inta abdominal infections : Spticemia : Meningitis ; skin and soft tissue infection;infections of bone and noints; Pelvic infalammatory disease, endometritis gonorrhea.
Dosage: 1gm or 2gm every 12 hrs. Severe infction : 8 gm per day. Gonococcal urethritis : 500mgl. M single dose.
Contraindications: Hypersensitivity to cephalosproins and penicillins.
Special Precautions: Severe biliary obstruction or hepatic disease, Prothormbin time should be monitored, premature infants and neonates.
Pediatrics: Safety not established in age below 12 years.
Pregnancy: Use only, if clearly indicated.
Lactation: Use with caution; secrected in breast milk in low amounts.
Side effects: Allergic reactions, reversible neutropenia,Transient rise in SGOT. SGPT & alkaline phosphatase. eosinopilia , positive direct Coom’s test anemia & reduced hematocrit.
Drug interactions: Enhances nephrotoxicity by aminoglycosides, Disulfiram-like reaction with alcohol, Potentiates anticoagulants.