Benzyl Pen
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PENICILLIN-G (BENZYL PENICILLIN): It is narrow spectrum with limited activity against agrm positive bacteria. May bacteria areinherently insensitive to PnG because in them the target enzymes and penicillin binding protein are located deeper under lipoproteing barrier where PnG is unable to penetrate.
Indications: Streptococcal infections like Pharyngitis, otitis media, scarlet fever, rheumatic fever, Pneumococcal like otitis media, meningitis, osteomyelitis. Gonorrhoea. Sypilis, Dephtheria. Tatanus, gas gangrene. Trench mouth, Rat bite fever.
Dosage: Sod, Penicillin G. infection : 0.5-5 MU i.m./i.v. 6-12 hrly. Pot Penicillin-G oral use : 2-8 lac U Q.I.D. 1hrs after food.
Contra-indications: Hypersensitivity, Allergic diathesis, rash, tiching, urticaria, fever, wheezing angioneurotic edema.
Special Precaution : A scratch test or intradermal test may be performed first.
Side-effects : Paint at i.m. injection site, nausea on oral ingestion, mental confusion, muscular, twitching, convulsions, coma, CNS stimulation, hallucinations, convulsions
Drug Interaction : Probenecid Increases and rolongs blood levels. Effects reduce by bacteriostatic agents like chloramphenicol and tetracycline.