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ITRACONAZOLE: It is a synthetic triazole antifungal agent and is closerly related to ketoconazole but has fewer adverse effects and wider spectrum of activity. It is extensiverly metabolised by the liver, prior to being excreted in the inactive form in urine and bile.
Indications: Dermatophytoses, onychomycoses tinea versicolor, cytabeiys cabduduasus, orophrayngeal candidiasis, vulvodvaginal candidiasis (CMC), oculomycoses systemic mycosis.
Contraindications: Hypersensitivity to other azoles
Dosage: 100-200 mg in single or divided doses
Side-Effects: Nausea, vomiting, rash pruritus, pedaloedema, depression, ziziness vertigo, parethesia, impttence and loss of libido
Special Precautions: Hepatic imparment
Pediatrics: Nto recommended.
Pregnancy: Contraindicated.
Lactation: Use with caution.
Drug Interactions: Terfenadine, astenuzike ckiserube ir dugixube, oral anticoagulants, phenytion, rifampicim, INH and H-2 antagonists,oral hypoglycaemic agents.