Giris
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GRISEOFULVIN: It is active against dermatophytes, including. Epidermophyton, Trichophyton, Microsporum etc. But not against Candida and other fungi, causing deep mycoses.
Indications: Fungal infections of skin; nails and scalp. Tinea and beard, anthlete’s foot
Dosage: Adults: 500-1000 mg daily with meals as in single dose or divided doses.
Children: 10 mg/kg body wt (125-250mg) daily in single or divided doses.
Contra-indications: Severe liver disease. Prophyria, monilial infection, SLE hypersensitivity.
Special Precautions: Long term use.
Pediatrics: Reduced dose necesary.
Pregnancy: Safety not established.
Lactation: Use with caution.
Elderly: Safe.
Side-effects: Drowsiness, headache, gastric distress, urticaria, potosensitivity.
Drug Interactions: Reduces efficacy of oral anticoagulant and failure of contraceptives. Baiturates reduces its effciency. may caukse headche dyspnoea, nausea, flushing.
Others: alcohol.