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MOXIFLOXACIN : The bactericidal action of moxifloxacin results form the intericidal with toposisomerase it and IV (DNA gyrase). Toposisomerase are essential enzymes that contrao DNA topology and assist in DNA replication. repair and transcription.
It is effective against Blactam and macrelide resistant bacteria.
Indications: Treatment of acute Bacterial Sinusitis Acute Bacterial Exacerbation of chronic Bronchitis and Community Acquired Pneumonia in adult patients (18 years of age and above)
Dosage: 400mg tablet orally every 24 hours.
Contraindications : Hypersensitivity
Special Precautions : Quinlones may cause CNS events including inervousness, agiltaion, insomnia anxiety nightmares or paranoia, pregnacy women. The safety and effectivenss of moxifioxacin in pediatric patients, adolescents (less than 18 years of age). pregnat women and lactaing women have not been established. It should be used with caution when given concurrently with cisapride, erythormycin, antipsychotics, and tricyclic antidepressants drugs. It should with caution with ongoingproarrhythmic conditions such as clinically significantbradycardia, or acute myocardial ischaemia, know or suspected CNS disorders or in the presence of other risk factor that may predispose to seizures or lower tha seizure threshold.