Norflox
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Noroxin (Norfloxacin)
US Brand: Noroxin
Manufacturer: Other
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NORFLOXACIN : Norfloxacin penetrates into the bacterial cells much more readily than nalidixic acid and exerts a potent bactericidal effect by inhibition of the A subunit of bacterial DNA gyrase an essential enzyme involved in DNA replication, precipitating a sequence of events leading to lysis of the bacteria. Its oral bioavailability is 40% Excretion occurs both in urine as well as in faeces.
Indications: Uro-genital infections, Typhoid fever. Acute bacterial gastroenteritis. Gonorrhoea. Prophylaxis of sepsis in neutropenic patients
Dosage: Typhoid fever 400 mg twice daily for 14 days UTI: 400 mg twice daily for 3 days to 12 weeks Gonorrhoea: 800 mg as single dose. Acute bacterial gastroenteritis: 400 mg 2-3 times daily for 5 days. 2-3 times daily upto 8 weeks.
Contra-indications : Hypersensitivity to any quinolone. Pregnancy. Not recommended for use in children.
Special precautions: History of convulsions. Ensure hydration and urinary output. In moderate renal insufficiency, reduce the dose. To be used with caution in patients predisposed to seizures. Donot exceed recommended dose.
Paediatrics: Not recommended.
Pregnancy: Contraindicated.
Lactation: Use only, if clearly indicated.
Elderly: Safe.
Side-effect : Headache, dizziness, rash, heart burn abdominal cramps, diarrhoea, Anorexia, sleep disturbances, anxiety, irritability.
Drug Interactions : Raises theophylline and cyclosporine levels. Effects of warfarin potentiated. Probenecid reduces urinary excretion of norfloxacin. Others: Nitrofurantoin, oral anticoagulants, theophylline, cyclosporin. Antacids reduce absorption from GIT.