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BULAQUINE: It is a mixture of 3{-1-[4-6(methoxy 8-quinolinyl) amino] amino} ethylidenedithdro 2-(3H) furanone and it’s tautomers.

Indications: Treatment and prevention of relapse of P.vivax malaria.

Dosage: The exact dosage recommended for clinical use is 25mg once daily for 5 days. This should be given along with chlorroquinie for completed cure of malaria. It should be started from Day 2 of chloroquine therapy.

Contra-indications: Rheumatoid arthritis, systemic lumps erythematosus, concurrent administration of drug know to case heamolysis.

Special Precautions: There is no need to conduct a G 6PDH deficiency test before administering bulaquine. Howere in patients with confimed G 6PDH deficiency caution is necessay. Its use in pregnant and lactating womem should be avoided,as controlled trials to confirm its safety and tolerability in these conditions have yet to be undertaken. No studies have been done in children.

Side-effects: Clinical data generated so far has not shown any adverse drug reactions.

Drug Interactions: Specific studies with other drugs have not been undertaken except with chloroquine where it was concurrently used in phase II/III clinical trials without any advise effects.