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CHLOROQUINE: It is rapidly acting erythorcytic schizoniticide; controls most clinical attacks in 1-2 days with disappearance of parasites from peripheral blood. However it has no effect on pre and exo-erythrocvtic phases of the parasite and dose not prevent ralanes in vivax and ovale malaria. P. falciprum has acquired sogmofocamt resostamce. Chloroquine. Is active against Entamoeba histolytica and Giardia lamblia also and has anti-inflammatory. local irritant. local anaestjetoc, weak smooth muscle re;axamt antihistaminic and antiarrhythmic properties.

Indication: Malaria, extra intestinal amoeblasis, giardiasis, rheumatoid arthritis, photogenic rections, infectious monocleosis.

Dosage : 1gm stat followed by 500mg after 6hrs and 500mg daily for next two days.

Contra-interactions: Pregnancy, liver damage severe G.I. & haemato;pgoca; diseases, eye impairment.

Special Precautions: Inject able form not be used in children below 5 yrs G-pd deficiency, peripheral neuropathy, opthalmic exmination redquired during prolonged therapy.

Side-effect: Nausea, vomiting, itching, headache. loss of vision due to retinal damage and comeal deposits. Loss of hearing, rashes, photo allergy mental disturbanes, yopathy and gerying or hair.