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Auranofin

INDICATIONS : Progressive rheumatoid arthritis.

CONTRAINDICATIONS: Severe hepatic disorders, bone marrow aplasia exfoliative dermatitis, necrotising enterocolitis, pulmonary fibrosis, SLE.

SAFETY PROFILE : Reproductive age group women should use effective contraception during therapy and at least 6 months after therapy, blood counts and urinary protein should be monitored.

ADVERSE EFFECTS : Blood dyscrasia, ulcerative enterocolitis, thrombocytopenia, pulmonary fibrosis, psychosis.

DOSAGE: Initially 6 mg. daily as single or 2 equally divided doses for 3-6 months.
Dose may be increase to 9 mg/day if response is inadequate.

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