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Recommanded drugs

• Terbutaline

BAMBUTEROL: It is an oral produrg of terbutaline with a prolonged druation of bronchodilaotr action that allows once-daily administration. It is an inactive site-specific prodrug that delivers active terbutaline only to the target tissue i.e. lung.

Clinical studies have shown that bambuterol is as effective as other oral and inhaled B2-agonists including salbutamol, terbutaline and salmeterol, and theophlline (both conventional and controlled release formulations).

Indications :Maintenace treatment of bronchial astham, Nocturnal astham, COPD.

Dosage : Adults : 10mg tablet once daily in the evening may be increased to 20mg after 1-2 weeks.

Contra indications : hypersensitivity to any of the ingerdients or terbutaline, Hepatic impairment liver, cirrhosis or severly imaired liver function.

Special Precautions : Dose should be reduced in patient with severely imaired renal function, care should be taken while prescribing abmbuterol in patients with genetic deficiencies of plasma cholinesterase, caution should be implemented in patients with severe ischaemic heart faliure.

Side - effects : Trimor, headache, muscle cramps, palpitation, fatigue and insomnia, Generally, these effects were mild nature and their incidence decreassed with time.

Drug Interactions : Bambuterol reversibly inhibits plasma cholinesterase which prolongs the neuromuscular blockade induced by succinlychline by upto four times. Hypertensive crisis and other adverse effects occur frequently with the concurrent use of bambuterol with monoamin oxidase inhibitors, bambuterol may partly or totally inhibit the effect of B-blockers.