Dopram
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It is safe, peripherally acting respiratory stimulant. It acts primarily by selectively stimulating peripheral carotid chemoreceptors. It elicits respiratory response within 20-40 seconds. It increases pulmonary ventilation.
INDICATIONS: Postanesthetic use, Drug-induced CNS Depression.
DOSAGE: Postanesthetic use: I.V. infusion at 0.5-1.5mg/kg Max 4 mg per kg. Drug-induced CNS Depression: Priming dose 2mg/kg I.V. Repeat in 5 minutes and then every 1-2 hours until the patient awakens. Total maximum daily dose 3 grams.
CONTRA-INDICATIONS: Severe heart diseases and hypertension, severe COPD, epilepsy, cerebral oedema, hyperthyroidism, ischemic heart disease, status asthmaticus, epilepsy, convulsive disorders, phaeochromcytoma, recent cerebrovascular accident, children under 12.
SIDE-EFFECTS: seen only in overdosage. Hypertension, tachycardia and fasciculations; agitation, confusion and dyspnoea.