Doxobid
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Methylxanthines phosphodiesterase inhibitors. Doxofylline is a new generation long acting oral methylxanthine derivative.
INDICATIONS: For maintenance therapy in patients suffering with Asthma and Chronic Obstructive Pulmonary Disease (COPD).
DOSAGE: Adult: 400 mg once a day. Single dose administration in the evening reduces nocturnal symptoms and helps to keep the patients complaint free during the day. However, in certain cases 400 mg twice daily is recommended on the basis of the clinical resopons.
CONTRA-INDICATIONS: Hypersensitivity to doxofylline and other methylxanthine devivatives. Methylxanthines are not recommended for therapy of asthma exacerbations.
SIDE-EFFECTS: Doxofylline has a prolonged bronchodilator effects, and unlike theophylline it has least adenosine interactions i.e., no CNS and CVS side effects. There is no sleep disturbances and no effects on secretions with doxofylline. It is highly safe in smokers.