Singulair
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Singulair (Montelukast)
US Brand: Singulair
Manufacturer: Other
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Recommanded drugs
It is a competitive leukotriene antagonist. It binds with high affinity to the LTD4 receptor, inhibiting bronchoconstriction. Cysteinyl leukotrienes (LTC4, LTD4, LTE4) are important proinflammatory mediators in asthma and also they have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma. They also play an important role in aspirin induced asthma.
INDICATIONS: Montelukast is indicated for the prophylaxis and chronic treatment of asthma in adults and pediatric patients 6 years of age and older.
CONTRA-INDICATIONS: Hypersensitivity, pregnancy and lactation.
SPECIAL PRECAUTIONS: Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Montelukast should not be abruptly substituted for inhaled or oral corticosteroids. Patients with known aspirin sensitivity should continue avoidance of aspirin or non- steroidal anti-inflammatory agents.
SIDE-EFFECTS: Headache, rash, dyspepsia, dizziness, and abdominal pain, diarrhea, sinusitis, and otitis media.
DRUG INTERACTIONS: Phenobarbital, rifampin or valproate.