Aciphex
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Aciphex (Rabeprazole) ( Pariet in Canada)
US Brand: Aciphex (Rabeprazole)
Manufacturer: Other
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It is proton pump inhibitor that suppresses gastric acid secretion by specific inhabitation of the H+/K+ ATPase in the gastric parietal cell.
INDICATIONS: Symptomatic erosive or GORD active duodenal Ulcer, active benign Ulcer, H-Pylori positive duodenal ulcers.
CONTRAINDICATIONS: Hypersensitivity to any component of the formulations.
SAFETY PROFILE: Oesophageal or gastric malignancy should be excluded prior to commencing treatment of rabeprazole, treatment should be stopped immediately at the recurrence of skin lesions.
ADVERSE EFFECTS: Darrhoea, dyspepsia, asthenia, flatulence, non-specific pain eructiation, leg cramps, UT infections, abdominal pain, Flu syndrome, dysuria.
DRUG INTERACTIONS: Ketoconazole level reduce by 1/3, if Co-administered with rabeprazole.
DOSAGE: Adults / Elderly: Active duodendal ulcer and active bengin gastric ulcer: 20 mg be taken once daily in the morning. Some patient with active duodenal ulcer may respond to once 10 mg tablet to be taken once daily in the morning. Erosive or uncreative gastro-oesophageal reflux disease (GORD): 20 mg once daily can be used.
Eradication of H-pylori: it is indicated for H-pylori positive duodenal ulcers, as part of the eradication programme with appropriate antibiotics.