Anthraquinones
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Senna is obtained from leaves & pod of certain Cassia sp, while Cascara sagrada is the powdered bark of the buck-thron tree. Anthraquinone glycosides thus obtained are unabsorbed in the small intestine; they are passed to the colon where bacteria liberate theactive anthropo form; which either acts locally or is absorbed in circulation.
INDICATIONS: Atonic constipation, Bowel evacuation for radiological examination.
CONTRA-INDICATIONS: Intestinal obstruction, spastic constipation, electrolyte imbalance, lactation.
SIDE-EFFECTS: Nausea, vomiting skin rashes, fixed drug eruption, Regular use (4-12 mths) causes colonic atony and mucosal pigmentation (melanosis).